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CFDA 93.866: Aging Research

NIA's primary CFDA for research on aging, Alzheimer's disease, and Alzheimer's-related dementias (AD/ADRD). Funding has expanded substantially due to the Alzheimer's Accountability Act bypass-budget process.

Typical award
R01: $250K-$500K direct/year for 4-5 years. R21: up to $275K total over 2 years. P30 Alzheimer's Disease Research Centers (ADRCs): $3M-$5M/year.
Eligible applicants
  • Research universities and IHEs
  • Academic medical centers
  • 501(c)(3) research institutes
  • Small businesses (SBIR/STTR for therapeutic + tech development)

What this CFDA funds

Basic biology of aging research, Alzheimer's disease and AD/ADRD studies, geriatrics and clinical care research, behavioral and social research on aging, training programs (T32, F-series, K-series), and Alzheimer's Disease Research Centers (ADRCs). Recent priorities: precision medicine for AD, dementia disparities, caregiver research, and aging biomarkers.

What winning applicants look like

AAU research universities, NIA-designated ADRC institutions, and academic medical centers with strong geriatrics + neurology departments. The bypass-budget for Alzheimer's research means NIA success rates have been higher than NIH average — particularly for AD/ADRD-focused proposals.

Common pitfalls + things to know

Distinguish between aging-as-context (an R01 about hypertension in older adults) and aging-as-mechanism (an R01 about cellular senescence). NIA prioritizes the latter for basic biology mechanisms. AD/ADRD-tagged proposals route to AD-specific review panels with separate paylines.

Related CFDAs to also explore

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Always verify in the official source. CFDA program details, eligibility, and award ranges change with each annual NOFO cycle. Confirm at sam.gov/content/assistance-listings or the agency's program office before you build an application strategy. This page is editorial reference, not an official agency notice.