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HHS Acquisition Rules

Federal Register rules, proposed rules, and notices from Department of Health and Human Services (HHS) and its acquisition components — sorted newest first. HHS operating divisions (NIH, CDC, CMS, FDA) buy under one umbrella but with very different evaluation cultures. Watch NIH protest decisions for what evaluation language withstands challenge on R&D contracts.

Proposed Rule

Request for Information; Clinical Laboratory Improvement Amendments of 1988 (CLIA) Regulations

Clinical laboratory testing technology has advanced significantly since the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations were implemented in 1992. This request for information (RFI) seeks input from the public regarding various topics related to the CLIA regulations, including: breath testing; laboratory processes and procedures; emergency preparedness, biosafety and biosecurity, and cybersecurity; and specialty testing areas. Responses to this RFI may be used to help in

DEPARTMENT OF HEALTH AND HUMAN SERVICES · Published Jul 16, 2026

Proposed Rule

Medicare and Medicaid Programs; CY 2027 Payment Policies Under the Physician Fee Schedule and Other Changes to Part B Payment and Coverage Policies; Medicare Shared Savings Program Requirements; and Medicare Prescription Drug Inflation Rebate Program

This proposed rule addresses: changes to the physician fee schedule (PFS); other changes to Medicare Part B payment policies to ensure that payment systems are updated to reflect changes in medical practice, relative value of services, and changes in the statute; codification of establishment of new policies for: the Medicare Prescription Drug Inflation Rebate Program under the Inflation Reduction Act of 2022; the Ambulatory Specialty Model; updates to drugs and biological products paid under Pa

DEPARTMENT OF HEALTH AND HUMAN SERVICES · Published Jul 16, 2026

Final Rule

Designated Placement Requirements Under Titles IV-E and IV-B for LGBTQI+ Children; Rescission

This rule finalizes the removal of the requirements issued in the Designated Placement Requirements Under Titles IV-E and IV-B for LGBTQI+ Children final rule that was published on April 30, 2024 (hereafter referred to as the 2024 final rule). The 2024 final rule required title IV-E/IV-B agencies to ensure that a Designated Placement is available for all children who self-identify with an alternative sexual orientation or self-identify as something other than their sex in foster care who request

DEPARTMENT OF HEALTH AND HUMAN SERVICES · Published Jul 14, 2026

Proposed Rule

Drug Establishment Registration and Drug Listing Requirements for Establishments Engaged in Distributed Manufacturing and Certain Foreign Establishments

The Food and Drug Administration (FDA, the Agency, or we) is proposing to amend the drug establishment registration and drug listing requirements with respect to establishments engaged in distributed manufacturing and foreign drug establishments. This action, if finalized, will provide a pathway for a distributed manufacturing establishment that manufactures drugs at multiple different physical locations to register as a single drug manufacturing establishment and align drug establishment regist

DEPARTMENT OF HEALTH AND HUMAN SERVICES · Published Jul 13, 2026

Final Rule

New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of Sponsor

The Food and Drug Administration (FDA or we) is amending the animal drug regulations to reflect application-related actions for new animal drug applications (NADAs), abbreviated new animal drug applications (ANADAs), and conditionally approved new animal drug applications (CNADAs) during January, February, and March 2026. The animal drug regulations are also being amended to improve their accuracy and readability.

DEPARTMENT OF HEALTH AND HUMAN SERVICES · Published Jul 7, 2026

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